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Mifeprex is used to end an early pregnancy that is not further along than 70 days after the first day of your last menstrual period. It also comes in a generic form with the name Mifepristone. It combines with the consumption of the medicine Misoprostol (Cytotec) to end a pregnancy.
Blockage of a pregnancy hormone, Progesterone, and widening cervix to stop developing pregnancy parts is possible with consumption of Mifeprex. This widening happens because the fetus gets separated from the ruptured lining of the uterus that lacks oxygen and required nutrition.
Mifeprex appears in light yellow and contains a few inactive ingredients such as microcrystalline cellulose, magnesium stearate, corn starch, colloidal silica anhydrous.
Everything you need to know to buy Mifeprex online & How to use it?
Consume Misoprostol containing 800 mcg (200 mcg each of 4 pills) after the 2-3 days of Mifeprex pill consumption. Insert Misoprostol pills under the tongue. They should not be chewed, crushed, broken, and swallowed. But after 30 minutes it can be consumed without water and that too after it completely melts under the tongue.
Misoprostol is a prostaglandin analog that leads to the contractions of the womb. When the uterus contracts, it tries to reveal out or push out the pregnancy remaining. During this, women experience heavy bleeding and cramps for a couple of hours or days.
Dosages and administrations with Mifeprex
Intrauterine pregnancy termination is possible medically with the use of Mifeprex. The Mifeprex dosage pattern involves oral consumption of 1 Mifeprex tablet (200mg) with water on the first day of medical pregnancy termination. For faster action, advice on the medication is to take without a meal
The intake of pills is possible up to 9 weeks gestation based on the first day of amenorrhea or last menstrual period. For this treatment, the pregnancy is in consideration from the first day of amenorrhea in a presumed 28-day cycle, ovulation occurring at mid-cycle.
Consume Mifeprex initially and after three days follow the oral intake of Misoprostol 800mcg (4 pills of 200mcg). A trained medical professional may administer Misoprostol, or it can also be self-administered by the woman. If the abortion does not occur after administration of Misoprostol, a second dose with 400mcg is likely to administer orally.
Usually, the patient using Mifeprex should return for a follow-up visit after 7-14 days of administration. The follow-up is to confirm that a complete pregnancy termination has occurred with the help of a clinical examination or USG scan. There is a risk of fetal malformation if the patients have an ongoing pregnancy at this follow-up visit. In such a case, surgical termination might be advisable.
It is essential to determine the duration of pregnancy from menstrual history and by clinical examination. If the period of pregnancy is uncertain, ultra-sonogram (USG) scan is a must. In case of suspicion of ectopic pregnancy, usage of USG eradicates pregnancy.
A gynecologist administers Mifeprex after gestational age assessment of the fetus. In case of negative results, the advice might be to diagnose ectopic pregnancies. The gynecologist should also be able to perform the surgical intervention in cases of severe bleeding or incomplete abortion.
For Patients Using Mifeprex Tablets
- This medicine is prescribed by your doctor, and the treatment requires three visits.
- At the first visit, a prescription of one Mifeprex tablet is likely to happen. Two days later, on the second visit, you will be prescribed another four pills of Misoprostol. During the third visit after two weeks, your doctor will confirm the status of your pregnancy. The process may include an ultrasound exam (sonogram) for confirmation of abortion.
- There might be bleeding and cramps for two to four weeks with Mifeprex consumption. Consult your doctor if there’s little or no vaginal bleeding after the medicine consumption.
- There might be chances to have a surgical abortion to end the pregnancy ultimately. Also, surgery is in place if any tissue is still present in the uterus even after Mifeprex consumption.
- It is mandatory to inform your doctor if you are using an IUD (intrauterine device). Removal of IUD will take place before using the medicine.
What Are The Contraindications?
Administration of Mifeprex contraindicated in patients who have:
- history of Mifeprex and Misoprostol allergy
- suspected or confirmed an ectopic pregnancy
- migraine issues
- IUD in place
- chronic adrenal failure
- bleeding disorders
- anticoagulant, corticosteroid therapies
- inherited porphyria
- severe uncontrolled asthma
Above mentioned issues are not a complete list of contraindications, but in case you face any other, talk to your doctor and find suggestions on the other problems.
Mifeprex might turn out to be an issue if a patient has no adequate access to medical facilities. In turn, she needs emergency treatment in a few cases. The cases arise in the form of an incomplete abortion, blood transfusions, and emergency resuscitation.
Warning and precautions during treatment with Mifeprex
Mifeprex is not a recommendation to patients with renal failure, hepatic failure, and malnutrition. The administration of Mifeprex must be under the supervision of a certified gynecologist.
Currently, there are no data on the safety and effectiveness of Mifeprex in women with chronic diseases. These diseases include heart disease, hypertension, liver dysfunction, respiratory or kidney disease, insulin-dependent diabetes, severe anemia, and heavy smoking. Women above 35 years of age who smoke need treatment with great caution.
There is definite evidence of human fetal risk, and studies have revealed such abnormalities in animals and humans. The survey confirms with a base with regards to data from investigation and marketing experience. Also, benefits can be undervalued in the use of the drug for pregnant women when compared with the risks involved.
Patients should be well aware of the Mifeprex administration and its effects. They must understand the necessity of the treatment and the importance of doctor visits.
There are massive chances of another pregnancy occurring even after the completion of abortion. So, contraception must be initiated soon after using Mifeprex before the woman resumes sexual intercourse.
Please note that clinical examination is imperative to confirm the complete pregnancy termination after the treatment.
Few women might face issues such as a decrease in red blood cell count, hematocrit, and hemoglobin concentration. The drop might happen in case the vaginal bleeding is heavy.
Comments On Using Mifeprex And Misoprostol
- Never leave behind without medication for cramps or gastrointestinal symptoms. These might be usual during the time immediately following the Misoprostol intake.
- Regimen effectiveness is likely and may be lower in a few cases. The cases might occur when Mifeprex administration is less than 24 hours and more than 48 hours.
- The effect of Misoprostol consumption leads to abortion within 2 to 24 hours in most cases. An appropriate location for the patient is essential in the administration of Misoprostol, taking into account that the initiation of abortion could begin within 2 hours of administration.
- Generally, to start the treatment of pregnancy termination, doctors consider the pregnancy date as the first day of the last menstrual period.
- Doctors determine the duration of pregnancy from menstrual history and clinical examination.
What Are The Drug Interactions?
There are no studies revealing Mifeprex interaction with a specific drug or food. However, there is a possibility that certain medications and substances such as ketoconazole, itraconazole, erythromycin, and grapefruit could inhibit the metabolism of Mifeprex. Also, dexamethasone, rifampicin, and certain anticonvulsants may induce Mifeprex metabolism.
Misoprostol, on the other hand, has not been found to interfere with the effects of aspirin. It does not exert a clinical impact on the absorption and antiplatelet effects of aspirin. Drug interaction studies between Misoprostol and several NSAIDs had no clinical implications for ibuprofen, diclofenac, piroxicam, aspirin, naproxen, or indomethacin.
Antacids continuing magnesium should be avoided during treatment with Mifeprex, as this may worsen diarrhea caused by Misoprostol.
There are restrictions on the usage of certain medicines to be used together. But, there are cases when two different drugs are used together, even if the interaction is possible to occur. Your doctor may choose to prescribe with the dosage depending on various factors.
You must report to your doctor the intake of all the medicines that you have been using. Below is the mentioned list of medications that you might be consuming for one or the other reasons. There might be a few different combos’ of intake you might follow as prescribed by your doctor.
Using Mifeprex with a lot of medicines is usually not recommended, but may be required in some cases. Your doctor may change the dose or suggest a way of your dosage intake with a combination of medicines. Misoprostol might commonly induce abdominal or stomach pain, diarrhea, back pain, dizziness, headache, and nausea. There are a few other side effects such as heavy vaginal bleeding, and unusual tiredness that occur rarely. Many women who receive Mifeprex, Misoprostol report side effects. Others say multiple reactions at a time. Consultation of the doctor is a must in case one or more side effects commence.
Women sometimes experience a few side effects that are less common, such as:
- acid or sour stomach
- fainting or lightheadedness when getting up from a lying or sitting position
- flu-like symptoms
- increased clear or white vaginal discharge
- itching of the vagina or genital area
- lack or loss of strength
- pain during sexual intercourse
- pain or tenderness around the eyes and cheekbones
- pale skin
- shaking chills
- stomach discomfort, upset, or pain
- stuffy or runny nose
- the tightness of the chest
- unusual bleeding or bruising
Other side effects that might occur are:
- chest pain
- fast or weak pulse
- feeling unusually cold
- lower back or side pain
- muscle pain or stiffness
- severe stomach and shoulders pain
- painful or difficult urination
- troubled breathing with exertion
- unusual or heavy vaginal bleeding
What Is The Case Of Overdose?
Intolerance studies report no severe side effects where the administration of Mifeprex in a single dose is higher than threefold that advised for pregnancy termination. In case of accidental massive ingestion, one may experience signs of adrenal failure. In the case of acute intoxication, one may require special treatment, including dexamethasone administration.
The toxic dose of Misoprostol in humans is not determined yet. However, the gastrointestinal problem is the only issue recorded even with a daily dose of 1600 mcg in total. Signs of an overdose include tremor, sedation, convulsions, breathlessness, abdominal pain, diarrhea, fever, hypotension, and bradycardia. In cases of overdose, seek medical attention right away.
Buy Mifeprex Online: FAQs
Now that you are done reading all the necessary information; here are some of the most frequently asked questions that patients have on how to buy Mifeprex online & use it to get the best results.
Will I Vomit After Taking Mifeprex Pill?
Some women do feel nauseating after taking the pill. Check with the doctor if you think nauseated or vomit; you may need an antiemetic drug to stop vomiting.
What To Do If I Accidentally Swallowed Misoprostol Pills?
Swallowing Misoprostol pills is safe yet causes a problem. There may be some gastrointestinal effects when the intake of tablets directly enters the stomach.
Where Should I Store Mifeprex?
Mifeprex needs to be stored at room temperature, preferably away from moisture, heat, and sunlight. Keep the container tightly closed with the cap provided. Always maintain a distance away from children and pets. Follow the guidelines as mentioned on the pack if you have any questions related to storing Mifeprex.
Does Mifeprex Affect My Fertility?
There are so minimal chances that impact health and fertility with the consumption of Mifeprex. Studies prove that women resume their menstruation within four weeks after pregnancy termination. Menstruation, in turn, leads to ovulation within a few weeks, and so a woman becomes pregnant just weeks after ending Mifeprex consumption.
When Can I Resume Sexual Intercourse After The Treatment?
Generally, women are advised not to participate in sexual intercourse for at least one week after the treatment with Mifeprex.
Will I Have Any Psychological Disturbances After Treatment?
Most of the time, it’s no. Early medical termination of pregnancy is often associated with an increase in psychological disturbances such as depression and anxiety. The risk of mental health problems is less with Mifeprex treatment.
Is It Safe To Buy Mifeprex Online?
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